Interleukin-17 and type 17 helper T cells in cancer management and research

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Interleukin-17 and type 17 helper T cells in cancer management and research

Since their recent discovery, T helper 17 (Th17) cells have been frequently detected in the tumor microenvironment of many malignancies, but their clinical implications remain largely unknown. Interleukin-17 (IL-17) detection is commonly related with poor outcomes in colorectal cancers, yet its presence is associated with antitumor responses in ovarian carcinomas. Numerous experimental models i...

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the role of interleukin-23 in stability of in vitro t helper-17 cells.

interleukin (il)-17-producing t helper (th)-17 cells have recently been explained as a distinct population  of  cd4+  t  cells which play an important  role in immunity against infectious agents. establishment of persistent phenotype of th17 cells and recognition of lineage-deviating factors are of most attractive goals in modern researches in immunology. although  il-6  and  tgf-β  are  freque...

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ژورنال

عنوان ژورنال: ImmunoTargets and Therapy

سال: 2014

ISSN: 2253-1556

DOI: 10.2147/itt.s56529